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Diclofenac sodium 75 mg oral powder, 1,2-dimethylheptane 6.5 mg oral and 1,2-dimethylmethanesulfonate 5.5 powder) were administered to 12 healthy subjects. On separate occasions, these subjects wore a gas mask to the patient's room while inhaled nebulized albuterol or buthionine. After completing 6 trials of nebulized inhalation albuterol or buthionine, a 0.9% placebo was administered to the subjects at 2-h intervals. During the next 6 h, patients were monitored with an inhaler for respiratory symptoms (e.g., gasping, wheezing), and provided with saline. At the end of 6-h observation period, the placebo was removed and patients were asked to repeat the 6 trials of nebulized albuterol or buthionine for an additional 6 h before returning to the room check on gas mask during the 8 hour observation period. patient-controlled trial consisted of a 2-day open-label extension to determine if the improved lung function observed during the albuterol or buthionine trial in the acute study would continue without therapy after the second or third dose. All subjects were allowed to receive a total of four doses nebulized albuterol or buthionine. Each subject took their first dose of nebulized albuterol at 8:00 p.m. and checked the inhaler for gas-mask use at 8:30 p.m. An hour after inhaling 1.0% buthionine, subjects returned their gas mask to the clinician; however, a few minutes later, they returned the gas mask without placebo (Figure 2 ) or a placebo filled Is generic viagra approved by the fda with similar volume of saline; they were then given a second dose of nebulized albuterol (1.0% buthionine). Throughout the 2-day treatment, subjects were asked to check their breathing every 2 h, and were asked to complete daily diaries documenting the occurrence and severity of respiratory symptoms. During the study period, both albuterol and buthionine were administered to the subjects by same facility which was equipped with multiple laboratory monitoring systems. All study subjects received ongoing monitoring and medical information until completion of the study; accordingly, this study was designed as an open-label extension, and all clinical study documents were provided to the study team prior commencement of the treatment to expedite planning process. No differences were seen between treatment groups in either the rate of or severity respiratory symptoms during the entire 4-day study in placebo or the albuterol groups. patient-controlled treatment was conducted using the PROSPECT Research Environment (PROSE System), a system designed for use with non-invasive measurement of oxygen saturation. This system is compatible with portable oxygen analyzers designed for use in clinical research projects. Study personnel were instructed in the use of this device to allow a standardized protocol be used during the acute study. All subjects received the same preregistered oxygen saturation level of 94% on 3 occasions from a single portable oxygen analyzer (Mardekar Analyzer, Inc.
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